|
KMID : 0616120080390030186
|
|
Korean Journal of Pharmacognosy
2008 Volume.39 No. 3 p.186 ~ p.193
|
|
|
Phytochemical Studies on Astragalus Root (3);Triterpenoids and Sterols
|
|
Jung Hye-Sil
Lee Eun-Ju
Lee Je-Hyun
Kim Ju-Sun
Kang Sam-Sik
|
|
|
Abstract
|
|
|
|
Astragali Radix, known as Huangqi, is the most important tonic in the traditional oriental medicine. It reinforces “qi” (vital energy), strengthens the superficial resistance and promotes the discharge of pus and the growth of new tissue. It has long been used as an anti-perspirant, anti-diuretic or a tonic. Eleven compounds were isolated from the hexane and EtOAc fractions from the roots of Astragalus membranaceus (Leguminosae) and their structures were identified as four triterpenoids [lupenone (1), friedelin (2), lupeol (3), soyasapogenol E (9)] and seven sterols [β-sitosterol (4), stigmastane-3,6-dione (5), 7α- hydroxysitosterol (6), 5α,6β-dihydroxysitosterol (7), 7-oxo-β-sitosterol (8), β-sitosterol glucoside 6’-O-palmitate (10), β-sitosterol glucoside (11)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. Among these compounds, lupenone (1), friedelin (2), lupeol (3), stigmastane-3,6-dione (5), 7α-hydroxysitosterol (6), 5α,6β-dihydroxysitosterol (7), 7-oxo-β-sitosterol (8), soyasapogenol E (9), and β-sitosterol glucoside 6’-O-palmitate (10) were isolated from this plant for the first time.
|
|
|
KEYWORD
|
|
|
Astragalus membranaceus, Leguminosae, triterpenoid, sterol, isolation and identification
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|